49ers vs. Cardinals live score, updates, highlights from NFL ‘Monday Night Football’ game

By | November 21, 2022
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The NFL heads back to Mexico City this week as the 49ers and Cardinals prepare to clash at the famous Estadio Azteca. It’s the fourth time the stadium has hosted an NFL game, and the second time these two teams have clashed south of the border.

The 49ers are riding a two-game winning streak, having taken down the Rams and Chargers. Christian McCaffrey has hit the ground running (literally) since being acquired from the Panthers in Week 7. He has racked up four total touchdowns in the last two games, and he’ll be looking for more against a shaky Cardinals defense.

MORE: Where is Christian McCaffrey from? Hometown, college and more

On the other side, the Cardinals picked up a 27-17 win over the Rams last time out despite missing starting quarterback Kyler Murray (hamstring). Colt McCoy got the start in Murray’s place but suffered a knee injury in the win. Murray has been ruled out once again tonight, so McCoy will be looking for a second straight win under center. 

The Sporting News is tracking live scoring updates and highlights from 49ers vs. Cardinals on “Monday Night Football.” Follow along for all the key moments from the Week 11 matchup in Mexico City.

MORE: Watch 49ers vs. Cardinals live with fuboTV (free trial)

49ers vs. Cardinals score

  1  2 3 4 F 
49ers 0 – – – –
Cardinals 3 – – – –

49ers vs. Cardinals live updates, highlights from ‘Monday Night Football’

All times Eastern.

8:41 p.m. — For the second time in a row, the 49ers do a great job on special teams to down the punt near the goal line. The crowd in Mexico City is loving that. 

8:39 p.m. — After two more short gains by McCaffrey, the Niners face 3rd and 2. They had it off to Deebo on a jet sweep, but the Cardinals are all over it and they shove him out of bounds short of the line to gain! This will be another punt for Kyle Shanahan’s offense. 

8:38 p.m. — San Francisco gets the ball back, and on the first play of the drive McCaffrey makes a catch for a gain of 11 yards to move the chains. 

Cardinals 3, 49ers 0

8:33 p.m. FIELD GOAL — Despite the rain drops, Prater’s kick sneaks inside the left upright to give Arizona an early lead. 

8:32 p.m. — Another incompletion brings up 4th down, and Matt Prater will come out for a field goal try.

8:31 p.m. — McCoy takes a deep shot to the end zone, but it’s just out of the reach of tight end Stephen Anderson. Niners corner Charvarius Ward looks like he may have been out of breath after that play, could be the altitude already having an impact. 

8:29 p.m. — After Hopkins makes another catch for a solid gain, James Conner catches a short pass and rumbles for a gain of 8. The Cardinals have the football around the Niners’ 30-yard line.

8:28 p.m. — Facing another 3rd down, this time McCoy makes a nice throw to Hopkins for a gain of 17 yards. That could help kickstart this offense. 

8:21 p.m. — Christian McCaffrey runs for a short gain on 1st down, then Garoppolo’s first pass of the night falls incomplete. On 3rd and 8, Garoppolo goes deep left for receiver Jauan Jennings, but he tripped over his own feet and that’ll fall incomplete as well. The night begins with back-to-back three-and-outs. 

8:18 p.m. — Terrible start to the night for Arizona. An opening sweep play gets blown up for a big loss, then after a short catch by DeAndre Hopkins , a McCoy incompletion brings up 4th and 10. Punt upcoming.

8:16 p.m. — We are underway, with the Niners kicking off first to the Cardinals’ offense. 

8:15 p.m. — Right on the stroke of kickoff, the rain has started to really come down. Just a reminder, Estadio Azteca is situated at a whopping 7,200 feet above sea level. The air is thinner, and that’ll probably result in some more tired than usual players. 

8:11 p.m. — It’s a cool and rainy night in Mexico’s capital city. Kickoff is drawing closer for this NFC West battle. 

8:10 p.m. — Compare that to the reaction the Niners got… Their fans travel well. 

8:09 p.m. — This is technically a home game for the Cardinals on the schedule, but you wouldn’t know it from the reaction they got running onto the field. 

8:01 p.m. — Colt McCoy prepares to start his second straight game for Arizona. His first one went pretty well, ending in a win over the Rams. 

7:57 p.m. — Deebo Samuel clearly has some fans down in Mexico. 

7:47 p.m. — Here come the Niners!

7:32 p.m. — Here’s the scene at Estadio Azteca in Mexico City. A famous and historic stadium hosts tonight’s edition of “Monday Night Football.”

6:55 p.m. — Kyler Murray is officially OUT tonight, per the Cardinals.

What time is the NFL game tonight?

  • Date: Monday, Nov. 21
  • Time: 8:15 p.m. ET (7:15 p.m. CT | 6:15 p.m. MT | 5:15 p.m. PT)

The game will kick off at 8:15 p.m. ET (7:15 p.m. local time, 6:15 p.m. in Arizona and 5:15 p.m. on the West Coast).

The venue is Estadio Azteca in Mexico City, where the weather forecast is for temperatures in the low 60s Fahrenheit. The stadium sits at an elevation of 7,218 feet above sea level, which is nearly 2,000 feet higher than the Broncos’ famously “mile high” stadium. The air is noticeably thinner at that height, so that could result in some tired players on the field.  

What channel is 49ers vs. Cardinals on today?

49ers vs. Cardinals will be broadcast nationally on ESPN. Joe Buck (play-by-play), Troy Aikman (color commentary) and Lisa Salters (sideline reporting) will be on the call.

Cord-cutters can watch the game with a subscription to ESPN+, the network’s streaming service. A live stream will also be available on fuboTV, which offers a free trial. Viewers in Canada can tune in with DAZN, which features every NFL game.

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